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The large supplies of eggs within each ovary are immature, or primordial, and must undergo growth and maturation each month. The eggs are stored within follicles in the ovary. Within a woman's lifespan, large numbers of follicles and oocytes will be recruited to begin the growth and maturation process. The large majority, however, will not reach full maturity. Most will die off in a process called atresia. Thus, only about 300-500 of these eggs will mature over a women's life span.
The maturation of eggs typically takes about 14 days and can be divided into 2 distinct periods. During the initial period, many eggs, as many as 1000, begin to develop and mature. The second phase of development requires gonadal hormone stimulation to stimulate further development. However, even though hundreds of eggs have begun to mature, most often only one egg will become dominant during each menstrual cycle, and reach its' fully mature state, capable of ovulation and fertilization. The remaining eggs/follicles will wither and die. Pre-pubertal girls do not produce the gonadal hormones that are necessary for the second phase of development, so the many eggs that started to mature will simply wither away. The large number of eggs that are used each month account for the steady decline in the female's total egg pool that occurs from birth to menopause.
In post-pubertal females, the dominant egg continues to develop, relying on hormones for growth and stimulation. When the egg becomes fully mature, the follicle surrounding the egg bursts, and releases a mature egg which travels through the fallopian tube toward the uterus. The egg is capable of being fertilized for a short period, about 48 hours. If the egg is not fertilized during this time, it will die, and in another week or so, a new cycle of egg maturation will begin.
This cyclic process of development continues through out a female's life until most or all of the eggs are depleted. This is the period of life known as menopause. This occurs sometime in the 4th or 5th decade of life, with the average age in the US being 51. Depletion of the egg pool anytime prior to age 40 is referred to as premature ovarian failure. Any female who receives treatment with drugs that damage the ovarian follicles is at risk to develop premature ovarian failure--even many years after the treatment has ended. The majority of young girls treated with chemotherapy will retain fertility initially, but may be at risk to develop premature ovarian failure. This knowledge may be important to consider for family planning.
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We have isolated and characterized cDNA clones of a gene family (P2) expressed in Oenothera organensis pollen. This family contains approximately six to eight family members and is expressed at high levels only in pollen. The predicted protein sequence from a near full-length cDNA clone shows that the protein products of these genes are at least 38,000 daltons. We identified the protein encoded by one of the cDNAs in this family by using antibodies to beta-galactosidase/pollen cDNA fusion proteins. Immunoblot analysis using these antibodies identifies a family of proteins of approximately 40 kilodaltons that is present in mature pollen, indicating that these mRNAs are not stored solely for translation after pollen germination. These proteins accumulate late in pollen development and are not detectable in other parts of the plant. Although not present in unpollinated or self-pollinated styles, the 40-kilodalton to 45-kilodalton antigens are detectable in extracts from cross-pollinated styles, suggesting that the proteins are present in pollen tubes growing through the style during pollination. The proteins are also present in pollen tubes growing in vitro. Both nucleotide and amino acid sequences are similar to the published sequences for cDNAs encoding the enzyme polygalacturonase, which suggests that the P2 gene family may function in depolymerizing pectin during pollen development, germination, and tube growth. Cross-hybridizing RNAs and immunoreactive proteins were detected in pollen from a wide variety of plant species, which indicates that the P2 family of polygalacturonase-like genes are conserved and may be expressed in the pollen from many angiosperms.
The germinal stage is the shortest stage of fetal development. It begins at conception when a sperm and egg join in your fallopian tube. The sperm fertilizes the egg and creates a zygote. The zygote begins its journey down to your uterus over the course of about one week. During this journey, the zygote divides many times, eventually creating two separate structures. One structure eventually becomes the embryo (and later, the fetus) and the other becomes the placenta. Cell division continues at a rapid pace. Eventually, the zygote turns into a blastocyst. The blastocyst arrives at your uterus and implants into your uterine lining. If implantation is successful, your body immediately begins producing hormones to support a pregnancy. This also stops your menstrual period.
In a cycle that ends with pregnancy, there are several steps. First, a group of eggs (called oocytes) gets ready to leave your ovary for ovulation (release of the egg). The eggs develop in small, fluid-filled cysts called follicles. Think of these follicles as small containers for each immature egg. Out of this group of eggs, one will become mature and continue through the cycle.
The fetus continues to mature and develop reserves of body fat. The brain develops most rapidly during this time. The fetus can see and hear most stimuli. Most internal systems are well-developed, but the lungs may still be immature.
During this stage, the fetus continues to grow and mature. The lungs are close to being fully developed at this point in pregnancy. The ninth month is mostly about putting the finishing touch on growth and brain development.
In the fourth week, the embryonic heart starts beating. The neural tube, which becomes the brain and spinal cord, forms. At this point, a woman has likely only been aware of her pregnancy for one week.
By the seventeenth and eighteenth week after gestation, the fetus shows a clear response to pain in multiple studies, and at least one brain pathway is mature enough to create a perception of pain. The fetus also practices breathing, crying, and breastfeeding in the womb. The fetal heart has beat over 20 million times and circulates about 55 quarts of blood per day. 59ce067264
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